2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1834S1
    Megestrol-d5
    Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].
    Megestrol-d<sub>5</sub>
  • HY-N7177
    Hydroxytanshinone IIA
    Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2/KDR/Flk-1.
    Hydroxytanshinone IIA
  • HY-128459
    N-Demethylerythromycin A
    N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic.
    N-Demethylerythromycin A
  • HY-13318R
    Oseltamivir acid (Standard)
    Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
    Oseltamivir acid (Standard)
  • HY-W016498R
    Paraxanthine (Standard)
    Paraxanthine (Standard) is the analytical standard of Paraxanthine. This product is intended for research and analytical applications. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine (Standard)
  • HY-B1069R
    Molsidomine (Standard)
    Molsidomine (Standard) is the analytical standard of Molsidomine. This product is intended for research and analytical applications. Molsidomine is an orally available, long-acting vasodilator that is metabolized in the liver to the active metabolite Linsidomine, an unstable compound that releases NO and acts as a vasodilator.
    Molsidomine (Standard)
  • HY-117229
    Sonidegib metabolite M48
    Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib.
    Sonidegib metabolite M48
  • HY-135328
    Norverapamil
    Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil
  • HY-137932
    Resveratrol-3-O-sulfate sodium
    Resveratrol-3-O-sulfate (sodium) is the metabolite of Resveratrol.
    Resveratrol-3-O-sulfate sodium
  • HY-139199
    4-Hydroxyphenylbutazone
    4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
    4-Hydroxyphenylbutazone
  • HY-G0007R
    Omeprazole sulfone (Standard)
    Omeprazole sulfone (Standard) is the analytical standard of Omeprazole sulfone. This product is intended for research and analytical applications.
    Omeprazole sulfone (Standard)
  • HY-135161
    EDDP perchlorate
    EDDP perchlorate is an N-desmethyl metabolite of Methadone by intestinal, hepatic, and cytochrome P450 (CYP) 3A4.
    EDDP perchlorate
  • HY-122489R
    DL-Laudanosine (Standard)
    DL-Laudanosine (Standard) is the analytical standard of DL-Laudanosine. This product is intended for research and analytical applications. DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity.
    DL-Laudanosine (Standard)
  • HY-127159
    Laurencin
    		Inhibitor
    Laurencin is a cyclic ether, which can be isolated red alga L. glandulifera. Laurencin prolongs the pentobarbitone-induced sleep time through inhibition of pentobarbitone metabolism.
    Laurencin
  • HY-W681822
    (R,S,S)-Dihydrotetrabenazine
    (R,S,S)-Dihydrotetrabenazine (R,S,S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM).
    (R,S,S)-Dihydrotetrabenazine
  • HY-W072459
    6'-Hydroxydihydrocinchonidine
    6'-Hydroxydihydrocinchonidine is a metabolite of Quinine (HY-D0143) (antimalarial agent).
    6'-Hydroxydihydrocinchonidine
  • HY-66008S2
    N-Acetyl mesalazine-13C6
    N-Acetyl mesalazine-13C6 is a deuterated labeled N-Acetyl mesalazine. N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis.
    N-Acetyl mesalazine-<sup>13</sup>C<sub>6</sub>
  • HY-A0115S2
    Ramiprilat-d4 hydrochloride
    Ramiprilat-d4 hydrochloride is deuterated labeled Ramiprilat (HY-A0115). Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research.
    Ramiprilat-d<sub>4</sub> hydrochloride
  • HY-137306
    Pergolide sulfone
    Pergolide sulfone is a Pergolide metabolite.
    Pergolide sulfone
  • HY-10873S1
    N-Desethyl Sunitinib-d4 TFA
    N-Desethyl Sunitinib-d4 (SU-12662-d4) TFA is deuterium-labeled N-Desethyl Sunitinib (HY-10873).
    N-Desethyl Sunitinib-d<sub>4</sub> TFA
Cat. No. Product Name / Synonyms Application Reactivity